The TL value can now be determined in human sublets (halthy and diseased) fig

Illustrating the P02 ai different levels (see also Fig4.4.1) OXYGEN CARRIAGE AND UNLOADING 1 Introduction 2 Oxygen dissociation curve, biological advantages of the aigmoid curve 3. Unloading of 02 in the tissues, coefficient of utilization. 4. Myoglobm 5 A-V 02difference, VQ2 max Introduction In a healthy man, at sea level, the artenal blood contains aboul 19m1 of 02/1O0 ml, of which 0.3 ml is in physical solution and trie rest, i e 18.7 ml is in combination with Hb Therefore, 02 is earned in the blood in two forms; (1)in physical solution, and (ii) as oxyhemagtobin (Hb02) The lension of a gas in blood is produced by only mat portion of gas which is in physical solution it follows that the Hb02 is not directly responsible For the tension produced by 02 (i.e. Pa02) When anenal blood reaches the tissue level, rt is exposed to a Ptissue O2 level which is very low, say <>